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. 2024 Feb 9;70:103081. doi: 10.1016/j.redox.2024.103081

Fig. 3.

Fig. 3

Effect of FBXL4 on HFpEF-induced changes in myocardial morphology, oxidative stress, and apoptosis. A: Representative gross images, Masson trichrome, H&E, and WGA staining; B: Percentage of interstitial fibrosis; C: WGA cross-sectional area; D–F: Representative images and pooled analysis of DCF/TUNEL staining depicting oxidative stress and apoptosis; G: ANP; H: BNP; I: β-MHC; J: Caspase3; K: Caspase9; and L: Caspase12. Insets: Representative immunoblots depicting atrial natriuretic peptide (ANP), brain natriuretic peptide (BNP), β-myosin heavy chain (β-MHC), cleaved caspase 3, cleaved caspase 9, and Caspase12 using specific antibodies. Mean ± SEM, n = 5 mice per group (4 replicates per mouse) (panel A–F) and n = 6 mice per group (panel G–L). Statistical significance was estimated by one-way ANOVA followed by Tukey's multiple comparison test, repeated measures ANOVA in R and Bonferroni adjusted test. ****p < 0.0001 between indicated groups.