Table 2.

Benefit of Hepatologist Care for Management of HCC

Study	Study Period	Country	Study population	HCC Outcomes
Davila et al	1994–2002	United States	1,873 adults with HCC from the SEER database	HCC surveillance with GI/hepatologist vs. PMD care (OR 2.8, 95% CI 1.73–4.53)
Dirchwolf et al	October 2018-October 2019	Argentina	301 patients with HCC diagnosis and known risk factors (advanced fibrosis/cirrhosis or chronic hepatitis B with Page-B score ≥10 points)	98.2% 0f cohort followed by hepatologist underwent surveillance (p<0.001)
Serper et al	January 2008 – December 2010	United States	3,988 patients from Veterans Administration (128 centers)	Hepatology care within 30-days of HCC diagnosis reduced mortality (HR 0.70; 95% CI 0.63–0.78)
Tapper et al	2001–2015	United States	389,257 adults with cirrhosis from Optum database	Hepatology care reduced mortality (0.78 [0.75, 0.80])
Yeo et al	2007–2016	United States	82,427 adults with cirrhosis from Truven Health MarketScan Research Database	HCC surveillance with PMD vs. GI/ID care (OR 0.48, 95% CI 0.46–0.52)
Marquardt et al	2011–2019	United States	Database of 1.1014 patients with cirrhosis and HCC from Parkland Health and Hospital System and University of Texas Southwestern Medical Center	Risk os screening within 1 year of HCC diagnosis if care provided by GI vs. PCP (OR 12; 95% CI 4.74–30.6) vs. GI+PCP (OR 11.8; 95% CI 4.89–28.5)