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. Author manuscript; available in PMC: 2024 Feb 20.
Published in final edited form as: J Hepatol. 2018 Dec 14;70(4):700–709. doi: 10.1016/j.jhep.2018.12.004

Fig.3: PDGF-D-stimulated secretion of VEGF-A and VEGF-C by human fibroblasts is dependent on ERK and JNK activation.

Fig.3:

(A, B) While evaluating the intracellular signaling mediating VEGF-A and VEGF-C secretion by fibroblasts, we found that ERK and JNK inhibition abrogated the stimulatory effects of PDGF-D on both VEGF-A (A) and VEGF-C (B) secretory levels, similarly to the PDGFRβ inhibitor, imatinib mesylate (IM). n=5–7 experiments in duplicate; **p<0.01 vs Ctrl; ^p<0.05 vs PDGF-D; ^^p<0.01 vs PDGF-D, using two-tail t test.