Fig. 2.

CAW improves memory in 5xFAD mice. Deficits in CFR performance, represented by the change in time freezing in the test phase relative to the habituation phase, were observed in control-treated female (A) and male (B) 5xFAD mice relative to CAW-treated WT mice (2g/L in the drinking water). A similar trend was seen as compared to WT controls, but it did not reach statistical significance in either sex. CAW attenuated these deficits in male and female mice such that the mice were not significantly different from either WT group. CAW treatment also restored the novel location preference in female 5xFAD mice (C). A similar but non-significant trend was also observed in male 5xFAD mice (D). n = 4–9, *p < 0.05, **p < 0.01, ***p < 0.001.