Table 2.

Clinical reports regarding the use of polyphenols in neurological disorders

Number of subjects	Treatment	Doses	Duration	Findings	Ref.
24 healthy males	240 ml FR orange juice	272 mg	2-weeks	Flavonoid-rich orange juice improves subjective and objective cognition in healthy middle-aged people for 6 hours.	159
52 subjects	Decaffeinated green tea catechins	336.4 mg	12 weeks	Consuming green tea catechins daily could have positive benefits on working memory.	160
30 healthy adults	Cocoa flavanols	520 mg and 994 mg	3 days	Cocoa flavanol beverages significantly reduced self-reported mental weariness, but this effect was only observed when the beverage was consumed.	161
37 healthy older adults	Flavanone	305 mg	8-weeks	An eight-week diet high in flavanones significantly improved global cognitive performance compared to a control diet low in flavanones.	162
50 children	Luteolin + quercetin + quercetin glycoside rutin	100 mg + 70 mg + 30 mg	26 weeks	Polyphenolic therapy improved communication, focus, and collaboration while reducing aberrant behaviors.	163
24 healthy adults	Flavanone	70·5 mg	1 week	The digit Symbol Substitution Test improved significantly, although other cognitive tests did not.	167
250 patients	Palmitoylethanolamide and luteolin	10:1 by mass	60 days	Neurological status, cognitive impairment, spasticity, pain, and daily life independence all showed statistically significant increases.	168
191 females	Soy-derived isoflavones	80 mg per day	6 months	Cognitive performance is unchanged	169
78 females	Cocoa polyphenols, single dose	250 or 500 mg per day	30 days	Cognitive performance is unchanged	170
50 females	Isoflavone supplement	60 mg per day	6 weeks	Improvement in visual recall and sustained attention	171
34 adults	Soy isoflavones	116 mg per day	12 weeks	Spatial working memory improved, but auditory and episodic memory did not.	172
27 participants	EGCG	135 or 270 mg		Cognitive performance is unchanged.	173