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ISG15 regulates autophagy by modulating ATG7 degradation: the model. When the expression of ISG15 is low or deficient, ATG7 is degraded by lysosome-mediated pathway, and the transformation from LC3-I to LC3-II is inhibited, with the autophagy level reduced (Left panel). In the cells with normal or high ISG15 expression, ISG15 can inhibit ATG7 degradation and promotes the transformation from LC3-I to LC3-II, resulting in autophagy (Right panel).
