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SARS-CoV-2 challenge of NP/RBD-vaccinated mice. (A) The vaccination and challenge regimen for female 4- to 6-week-old K18 hACE2 transgenic mice. (B) Quantification of virus concentrations in the lungs and nasal turbinate by plaque assay and Nluc activity in the lungs. The limit of detection (LOD) is 10 PFU/mL. (C) Body weight changes and percent mortality were monitored daily up to 11 DPI (n = 5/group). Data are presented as mean ± SEM.
