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Comparison of RBD-specific antibody responses in mice vaccinated with NP/RBD 6xHis protein treated with PR8 sera or PBS sera. (A) Mouse vaccine regimen. (B) ELISA analysis of RBD-specific IgG antibody levels in sera from A on Day 14 after vaccination (n = 5/group) (***P ≤ 0.001; **P ≤ 0.01). (C) Mouse vaccine regimen with or without CD4 T-cell depletion. (D) ELISA analysis of RBD-specific IgG antibody levels in sera from C on Day 14 after vaccination (n = 5/group).
