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. 2024 Jan 5;98(2):e01721-23. doi: 10.1128/jvi.01721-23

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Fig 5 — Effects of Tet deletion on liver viral DNA methylation in HBV transgenic mice. Percentages of CpG DNA methylation at each of the 11, 38, and 13 sites located within HBV nucleotide coordinates 341–711, 1215–1629, and 2264–2474, respectively, for the viral genome from the livers of HBV transgenic mice are shown. (A) Male and (B) female HBVTet2(fl/fl)Tet3(fl/fl)Cre(−) and HBVTet2(fl/fl)Tet3(fl/fl)Cre(+) mice. The viral transcription initiation sites for the X gene, the precore/pregenomic, the large surface antigen, and the middle/major surface antigen transcripts plus the CpG island are located at nucleotide coordinates 1310, 1785/1821, 2809, and 3159/3178 plus 1000–2000, respectively.