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. Author manuscript; available in PMC: 2024 Feb 20.
Published in final edited form as: Pharm Stat. 2019 Dec 22;19(3):291–302. doi: 10.1002/pst.1991

Table 4.

Signals generated by MaxSPRT and Bayesian methods using VSD influenza vaccine safety data during 2010–2011 influenza season.

Week Observed Expected Cumulative doses LLR Critical value Bayes lower CI Bayes upper CI Signal (MaxSPRT) Signal (Bayesian)

week 1 0 0.0000635 2 0.000 3.468 0.141 3.660 No No
week 2 0 0.0004074 10 0.000 3.468 0.141 3.659 No No
week 3 0 0.0006361 16 0.000 3.468 0.141 3.659 No No
week 4 0 0.0015739 48 0.000 3.468 0.141 3.657 No No
week 5 0 0.0149011 299 0.000 3.468 0.139 3.627 No No
week 6 0 0.0530657 955 0.000 3.468 0.136 3.544 No No
week 7 0 0.1538906 2808 0.000 3.468 0.129 3.342 No No
week 8 1 0.3755498 7729 0.355 3.468 0.345 3.888 No No
week 9 2 0.8393673 17822 0.576 3.468 0.308 3.492 No No
week 10 3 1.6540956 35663 0.440 3.468 0.455 3.103 No No
week 11 7 2.5440721 54904 2.629 3.468 1.042 3.834 No Yes
week 12 9 3.3651772 72542 3.219 3.468 1.153 3.727 No Yes
week 13 15 4.1043193 88592 8.544 3.468 1.791 4.577 Yes Yes
week 14 17 4.7263061 101862 9.487 3.468 1.860 4.513 Yes Yes
week 15 18 5.4139540 116501 9.039 3.468 1.790 4.245 Yes Yes
week 16 21 5.9908531 128847 11.331 3.468 1.969 4.400 Yes Yes
week 17 23 6.3116437 135672 13.053 3.468 2.094 4.525 Yes Yes
week 18 24 6.7721527 145642 13.138 3.468 2.076 4.419 Yes Yes
week 19 25 7.1411842 153628 13.466 3.468 2.082 4.368 Yes Yes
week 20 25 7.4691285 160766 12.672 3.468 2.007 4.211 Yes Yes
week 21 26 7.6449998 164584 13.470 3.468 2.057 4.255 Yes Yes
week 22 26 7.8169554 168370 13.064 3.468 2.020 4.177 Yes Yes
week 23 26 8.0741988 173899 12.479 3.468 1.966 4.066 Yes Yes
week 24 26 8.3038506 178849 11.980 3.468 1.921 3.972 Yes Yes
week 25 26 8.4930151 182989 11.583 3.468 1.885 3.898 Yes Yes
week 26 26 8.6873295 187172 11.189 3.468 1.849 3.824 Yes Yes
week 27 26 8.8479430 190705 10.874 3.468 1.821 3.766 Yes Yes