Forest plots for outcomes including rate per 100py (patient‐years), hazard ratios, confidence intervals, p values. Top panel: Forest plots showing overall MACE, components of MACE, and all cause death for the general cohort of men with ED. Objective (Obj) 1, exposed and unexposed to tadalafil. Middle panel: Forest plots for outcomes of men without known coronary artery disease but with risk factors for coronary artery disease (Obj 2). Bottom panel: Forest plots showing outcomes by dose. The lowest dose is the first quartile and the highest dose the fourth quartile (Obj 3). The first quartile represents 6.0 ± 1.3 tablets prescribed during the study period; second quartile represents 16.1 ± 4.9 tablets; third quartile represents 42.2 ± 12.2 tablets; and fourth quartile represents 288.6 ± 327.6 tablets. ED, erectile dysfunction; MACE, major adverse cardiovascular events. NR, not reportable, total count less than or equal to 10.