Fig 4.
Omeprazole and AMCase inhibitor reduce airway hyperresponsiveness induced by Ascaris larval migration through the lungs (A) BALB/c mice were pretreated with omeprazole plus AMCase inhibitor or vehicle control before challenge by oral gavage with 2,500 eggs of Ascaris. (B) Larval burden was quantified from the lungs 8 days post infection. (C) Respiratory system resistance (RRS) was assessed after intravenous injection of increasing doses of acetylcholine (Ach) at 12 days post infection. (D) Body weight loss in mice was measured at 12 days post infection. (E) Type-2 cytokines were quantitated by ELISA from deaggregated lung supernatants. (n = 4, mean±S.E.M, *p<0.05, **p<0.01, ***p<0.001, ****p<0.0001 using two-tailed Student’s t-test (B) or one-way ANOVA followed by Tukey’s test for multiple comparison (C-E). Data are shown as representative of two independent experiments. Illustration generated by Biorender.com).