Figure 5.

Results of overall and cardiac mortality in relation to transmitral E/A ratio in the Strong Heart Study [74] (upper panel)) and classification of DD grades (I-IV) according to Mayo Clinic suggestions [21] (lower panel). It can be observed a parallel behaviour between clinic progression and prognostic value of different grade of DD: the increment of mortality in Strong Heart Study has an "U" behavior, where E/A ratio <0.6 (grade I of DD) and >1.5 (grades II, III, IV) are both main predictors of mortality DD = diastolic dysfunction, NYHA = New York Heart Association, MAP = mean atrial pressure