Table 1.

Influence of S. mutans SpaP A/B/C adhesion types on caries progression in high (P4a), moderate (P6), and low (P1) caries genotypes and phenotypes.

Typesa	n	DeFS-12 yb			n	DeFS-17 yb			ΔDeFS-5yc
		mean ± SD	Pd	mean diff (95% CI)e		mean ± SD	Pd	mean diff (95% CI)e	mean ± SD	Pd	mean diff (95% CI)e
P4a
SpaP A	19	3.7 ± 2.9	0.075	1.4 (−0.2, 2.9)	16	9.8 ± 11.0	0.51	3.4 (−1.6, 10.1)	6.0 ± 10.9	0.61	2.2 (−2.5, 8.7)
SpaP B	11	4.7 ± 5.0	0.13	2.3 (−0.6, 5.6)	9	12.0 ± 10.0	0.025	5.6 (0.0, 13.5)	6.1 ± 4.6	0.065	2.2 (−0.7, 5.8)
SpaP C	2	3.5 ± 0.7	0.34	1.1 (0.0, 2.2)	2	8.5 ± 5.0	0.35	2.1 (−2.7, 7.0)	5.3 ± 5.0	0.48	1.5 (−3.0, 6.0)
SpaP neg	42	2.4 ± 2.5	Ref.	Ref.	37	6.4 ± 6.3	Ref.	Ref.	3.8 ± 4.5	Ref.	Ref.
P6
SpaP A	25	3.2 ± 2.8	0.0077	1.7 (0.5, 3.0)	24	7.3 ± 6.0	0.033	3.3 (0.7, 5.9)	4.1 ± 4.2	0.11	1.7 (−0.1, 3.6)
SpaP B	17	3.9 ± 3.3	0.0013	2.4 (1.0, 4.3)	11	13.6 ± 16.8	0.0044	9.6 (1.8, 21.2)	8.4 ± 13.4	0.11	6.0 (−0.3, 15.0)
SpaP C	4	3.3 ± 2.5	0.11	1.8 (−1.2, 4.5)	4	7.3 ± 6.6	0.29	3.3 (−3.9, 11.7)	3.6 ± 5.4	0.84	1.1 (−2.6, 8.8)
SpaP neg	56	1.5 ± 1.7	Ref.	Ref.	54	4.0 ± 3.8	Ref.	Ref.	2.5 ± 2.8	Ref.	Ref.
P1
SpaP A	23	1.8 ± 1.8	0.42	0.2 (−0.7, 1.1)	21	6.3 ± 8.3	0.47	2.4 (−1.2, 6.6)	4.4 ± 6.8	0.40	1.9 (−0.8, 5.4)
SpaP B	17	3.1 ± 3.1	0.067	1.5 (−0.1, 3.0)	14	6.7 ± 4.3	0.013	2.8 (0.1, 5.2)	3.7 ± 3.2	0.048	1.3 (−0.7, 3.3)
SpaP C	6	3.0 ± 2.0	0.18	1.4 (−0.1, 3.1)	5	4.4 ± 3.6	0.95	0.4 (−3.0, 4.1)	1.8 ± 2.2	0.60	−0.7 (−2.6, 1.8)
SpaP neg	69	1.6 ± 2.1	Ref.	Ref.	56	4.0 ± 4.8	Ref.	Ref.	2.5 ± 4.0	Ref.	Ref.

^aHigh (P4a), moderate (P6), and low (P1) caries phenotypes with Swedish ethnicity defined by PRH1, PRH2 genetic variation.

^bCaries DeFS (Decayed, enamel-included, Filled Surfaces) at 12 and 17 years of age.

^cΔDeFS (5 y) = 5-year prospective caries increment from 12 to 17 years of age.

^d2-sided P value from Mann–Whitney U test.

^eMean difference estimate with 95% CIs by bootstrapping 1000 times.