Extended Data Fig. 1. Cumulative incidence risk (Aalen–Johansen) of the time-to-first treatment-emergent composite of major and clinically relevant nonmajor bleeding (primary outcome; safety analysis set).

Cumulative incidence (%) = Aalen–Johansen estimates of the cumulative probability for an event, calculated as 100 x (1 minus the Aalen–Johansen estimate of the survival function). Overall study period: Only treatment-emergent events that occurred during the overall study period are considered. Treatment-emergent events are those that occurred after the start of the study treatment and until the last dose of the study treatment plus 30 days.