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. 2023 Nov 27;4(2):100445. doi: 10.1016/j.xgen.2023.100445

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© 2023 The Authors

This is an open access article under the CC BY license (http://creativecommons.org/licenses/by/4.0/).

PMC Copyright notice

Emerging technologies to propel precision medicine of genetic cardiovascular diseases forward

Recent advancements in iPSC technology enable new insight into genetic cardiovascular diseases. In this review, we highlight novel innovations in (1) the generation of iPSC-derived cardiac cells for disease modeling, (2) the expansion of genetic tools and therapies, (3) the prediction of disease-linked genetic variants and patient response risk using functional and computation methods, (4) 3D and multi-cellular platforms, and (5) function-based pharmacogenetic testing and discovery. We provide perspective into how these complementary advancements (blue text) will continue to drive the future of cardiovascular precision medicine. Created with Biorender.com.