Illustration of an example iterative 2D/3D registration of the pelvis. The target image is a real pelvis X-ray image with tool overlay. Renderings of the initialization, ProST network registration estimation, and ground truth pose of the pelvis are illustrated on the left. The black arrow shows the difference between initialization and ProST registration poses. The target image, initial projection image, and the failed CMAES registration image from the initial are shown in the first row. The ProST registration image, successful CMAES registration image from ProST estimation, and an overlay image with DRR-derived edge in green are shown in the second row.