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. 2024 Feb 7;15:1325186. doi: 10.3389/fphar.2024.1325186

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Copyright © 2024 Perelló, Alberti, Torres, Ferrer, Perez, Bassissi, Gold, Raggi, Chertow and Salcedo.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Pharmacokinetics and Pharmacodynamics. (A) Hexasodium Fytate Maximum Plasma Concentration (C_max). Average C_max was significantly different between each hexasodium fytate group and placebo (p < 0.001); C_max values by visit were not significantly different within each treatment group (p = 0.631). (B) Mean Inhibition of Calcium-Phosphate (Hydroxyapatite) Crystallization. The average PD effect was significantly different between each hexasodium fytate treatment group and placebo (p < 0.001); the PD effect by visit was not significantly different within each treatment group (p = 0.652).