TABLE 4.
Influence of the assumed value for observed values below the limit of quantification in the final PK/PD model.
| Model | Emax, % inhibition | E0, % inhibition | EC50, µM | R2 |
|---|---|---|---|---|
| BLQ = 0 | ||||
| Estimate | 72.0 | 13.5 | 6.33 | 0.8418 |
| % RSE | 7.36 | 22.2 | 29.9 | |
| 95% CI | 61.4, 82.6 | 7.48, 19.5 | 2.54, 10.1 | |
| BLQ = LQ/2 | ||||
| Estimate | 75.9 | 8.78 | 5.48 | 0.8430 |
| % RSE | 6.34 | 43.44 | 32.11 | |
| 95% CI | 66.3, 85.6 | 1.13, 16.4 | 1.95, 9.01 | |
| BLQ = LQ | ||||
| Estimate | 81.4 | 2.59 | 4.66 | 0.8439 |
| % RSE | 6.02 | 211.9 | 35.1 | |
| 95% CI | 71.5, 91.2 | −8.43, 13.6 | 1.38, 7.93 | |
BLQ, below the limit of quantification; Emax, estimated maximum effect; E0, estimated minimum effect; EC50, hexasodium fytate concentration associated with 50% maximum effect; LQ, limit of quantification (0.758 µM); %RSE, 100*standard error/estimate.