Fig. 1.

Gene expression analysis of the radial and vertical growth phases of primary melanoma. Photograph (A) and photomicrograph (B) of PM09, depicting areas of radial and vertical growth used for laser capture microdissection. (C) List of sam genes shows that many cell adhesion receptors and ESTs are lost in the vertical phase (see Table 1, which is published as supporting information on the PNAS web site, for full list of gene names). Photomicrographs of CDH3 (D) and MMP10 (E) immunostaining in radial growth phase versus vertical growth phase melanoma, with high-power views of the radial growth phase (Left) and vertical growth phase (Right).