Table 1.
Key components of purine metabolic pathways in F. graminearum, and their orthologs in M. oryzae and S. cerevisiae.
| F. graminearum | M. oryzae | S. cerevisiae | Functions | |
|---|---|---|---|---|
| Purine de novo pathway | FgAde4 (FGSG_05278a) | MoAde4 | Ade4 | Phosphoribosylpyrophosphate amidotransferase (PRPPAT) |
| FgAde5,7 (FGSG_02506a) | MGG_11343a | Ade5,7 | Aminoimidazole ribonucleotide synthetase and glycinamide ribotide synthetase | |
| FgAde8 (FGSG_08429a) | MoAde8 | Ade8 | Phosphoribosyl-glycinamide transformylase | |
| FgAde6 (FGSG_09440a) | MoAde6 | Ade6 | Formylglycinamidine-ribonucleotide (FGAM)-synthetase | |
| FgAde2 (FGSG_10669a) | MGG_01256a | Ade2 | Phosphoribosylaminoimidazole carboxylase | |
| FgAde1 (FGSG_09453a) | MoAde1 | Ade1 | N-succinyl-5-aminoimidazole-4-carboxamide ribotide synthetase | |
| FgAde13 (FGSG_09185a) | MGG_03645a | Ade13 | Adenylosuccinate lyase | |
| Acd16 | MGG_04435a | Ade16, Ade17 | AICAR transformylase and IMP cyclohydrolase | |
| FgAde12 | MGG_17000a | Ade12 | Adenylosuccinate synthase | |
| FgImd1 | MoImd4 | Imd1-4 | IMD2-4 genes encode AICAR transformylase and IMP cyclohydrolase, IMD1 is a pseudogene. | |
| FgGua1 (FGSG_10358a) | MGG_00919a | Gua1 | GMP synthase | |
| FgAdk1 (FGSG_10737a) | MGG_01058a | Adk1 | Adenylate kinase | |
| FgAdk2 (FGSG_09162a) | MGG_03683a | Adk2 | Adenylate kinase | |
| FgAdo1 (FGSG_06932a) | MGG_06270a | Ado1 | Adenosine kinase | |
| FgGuk1 (FGSG_05956a) | MoGuk1 | Guk1 | Guanylate kinase; converts GMP to GDP | |
| FgNdk1 (FGSG_05972a) | MoNdk1 | Ynk1/Ndk1 | Nucleoside diphosphate kinase | |
| Purine salvage pathway | FgApt1 | MGG_17399a | Apt1, Apt2 | Adenine phosphoribosyltransferase |
| FgHpt1 | MGG_10052a | Xpt1 | Xanthine-guanine phosphoribosyl transferase | |
| Hpt1 | Dimeric hypoxanthine-guanine phosphoribosyltransferase; | |||
| Acd3 | – | Aah1 | Adenine deaminase (adenine aminohydrolase) | |
| Acd14 | MGG_04119a | Gud1 | Guanine deaminase | |
| Purine catabolic pathway | Acd1 | MGG_05630a | Amd1 | AMP deaminase |
| – | – | Pnp1 | Purine nucleoside phosphorylase | |
| FgIsn1 (FGSG_11629a) | MGG_02955a | Isn1 | Inosine 5′-monophosphate (IMP)-specific 5′-nucleotidase | |
| FgPhm8 (FGSG_06179a) | MGG_01783a | Phm8, Sdt1 | Lysophosphatidic acid (LPA) phosphatase, nucleotidase |
–, No homolog.aPredicted gene number (Homolog is present but not characterized).