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. 2024 Feb 20;15:1531. doi: 10.1038/s41467-024-45817-8

Fig. 1. CRISPR screens identify mediators of cellular collagen uptake.

Fig. 1

a Schematic of experimental approach for flow cytometry-based screening for uptake of collagen fragments. b Volcano plot of gene-level statistics of CRISPRi (inhibition) screen. Most significant gene hits are labeled and colored in red. RRA Robust Rank Aggregation score, LFC Log-fold change. c Volcano plot of gene-level statistics of CRISPRa (activation) screen. d Comparison of overall phenotype score between CRISPRi and CRISPRa screens; p = 2.2 ×10−16. Statistics: d Pearson’s correlation, two-sided. Source data are provided in Supplementary Data 1.