Fig. 2. Collagen-biosynthetic pathways are regulators of collagen uptake uniquely compared to screens for uptake of other cargoes.
a Ranked plot of Normalized Enrichment Scores derived from Gene-Set Enrichment Analysis (GSEA) of CRISPRi phenotype scores, using 10,561 Gene Ontology gene sets. Collagen-related gene sets are labeled and displayed in red. b Comparison of GSEA statistics for labeled collagen-related gene sets across screens for uptake of various cargoes26; screen method is indicated in parentheses. KD Knock-down. Statistics: GSEA algorithm (based on the Kolmogorov–Smirnov test), as described in the Methods section; unadjusted p-values are shown. Source data are provided as a Source Data file.