FIGURE 3.

Non-coding RNAs in pathogensis of ischemic reperfusion injuries, encephalopathy, and liver fibrosis. In diseases such as myocardial and kidney injury, as well as sepsis-associated encephalopathy, the dysregulated expression of ncRNAs plays a pivotal role in inducing ferroptosis. This dysregulation alters the expression of ferroptosis regulators, exacerbating the pathological conditions. Conversely, in liver fibrosis, the suppression of ferroptosis is attributed to the functional role of specific ncRNAs. Remarkably, inducing ferroptosis in the context of liver fibrosis has been demonstrated to have a reversing effect on the fibrotic process, highlighting the potential therapeutic significance of modulating ferroptosis through the manipulation of ncRNA expression.