TABLE 1.

Exosomal Ferroptosis-Related ncRNAs for treatment of different diseases.

Type of disease	Name of exosomal ncRNA	Origin	Effect on ferroptosis	Treatment method	Ferroptosis targets	Model	Results	References
MI	miR-26b-5p	Cardiomyocytes	Inhibitor	miR-26b-5p mimic	SLC7A11	In vivo	Improved cardiac function	Li et al. (2023b)
MI	lncRNA-Mir9-3hg	BMSCs	Inhibitor	Exosome injection	PRDX6	In vivo	Reduced cardiac infarct size, improved cardiac function, and ameliorated ferroptosis	Zhang et al. (2022c)
MI	miR-23a-3p	HUCB-MSC	Inhibitor	Exosome injection	DMT1	In vivo	Reduced myocardial injury in AMI mice	Liu et al. (2022)
Stroke	miR-124	M2-type microglia	Inhibitor	M2-exosomes with miR-124-3p overexpression	NCOA4	In vitro	Recovered OGD/R-induced HT22 cell injury	Wu et al. (2022b)
Stroke	circBBS2	UC-MSCs	Inhibitor	Exosome injection	miR-494/SLC7A11	In vivo	Relieved cerebral I/R injury	Hong et al. (2023)
Stroke	miR-760-3p	ADSCs	Inhibitor	Intranasal exosome injection	CHAC1/GPX4	In vivo	Improved the neurobehavior function	Wang et al. (2023)
Stroke	miR-194	BMSCs	Inhibitor	Exosome transfection	Bach/NRF2	In vitro	Protected against OGD/R-induced injury	Li et al. (2021b)
Hepatic Ischemia	miR-214-3p	HMSCs	Inhibitor	Exosome injection	COX2	In vivo	Attenuated transplanted steatotic liver IRI	Zuo et al. (2023)
Hepatic Ischemia	miR-29a-3p	HMSCs	Inhibitor	Exosome Transfection	IREB2	In vivo	Protected against Steatotic Liver IRI	Li et al. (2022a)
Hepatic Ischemia	miR-124-3p	HMSCs	Inhibitor	Exosome injection	STEAP3	In vivo	Supressed UVB light-induced vascular injury	Wu et al. (2022b)
Renal Ischemia	lncRNA TUG1	Human urine-derived stem cells	Inhibitor	Exosome injection	ACSL4	In vivo	Ameliorated IRI-induced AKI	Sun et al. (2022)
Wound Injury	MiR-17–92	MSCs	Inhibitor	Topical application	GPX4 and SLC7A11	In vivo	Improved angiogenesis during wound healing faster wound healing	Nie et al. (2023)
UVB-induced skin injury	circ-Ash1l	ADSCs	Inhibitor	Exosome injection	MiR-700-5p/GPX4	In vivo	Enhanced UV-induced skin damage	Zha et al. (2023)
DFU	circ-ITCH	BMSCs	Inhibitor	Subcutaneous exosome injection	NRF2	In vivo	Improved wound healing in DFU mice and reduced pathological damage	Shao et al. (2022)
HBV-GN	miR-223-3p	BMSCs	Inhibitor	Exosome transfection	ACSL4	In vitro	Protected against ferroptosis induced by HBx overexpression in podocytes	Yang et al. (2023b)
COPD	miR-26a-5p	EPCs of normal patients	Inhibitor	Exosome injection	PTGS2	In vivo	Alleviated CS-induced airway remodeling	Liu et al. (2023)
AF	miR-23a-3p	Cardiac fibroblasts	Inducer	Exosome blockade by GW4869	SLC7A11	In vivo	Reduced exosome secretion, fibrosis, inflammation, and ferroptosis	Liu et al. (2022)
Liver Fibrosis	miR-222	HBV-infected LO2 cells	Inhibitor	Exosome blockade by GW4869	TFRC	In vivo	Reduced ferroptosis	Zhang et al. (2022b)
IBD	mir-129-5p	HMSCs	Inhibitor	Exosome injection	ACSL4	In vivo	Improved weight, reduced disease activity index (DAI) scores, restoration of colon length and spleen size	Wei et al. (2023)
IDD	circ_0072464	BMSCs	Inhibitor	Exosome injection	NRF2	In vivo	Promoted matrix synthesis and proliferation	Yu et al. (2022)
Sepsis-Induced Lung Injury	miR-125b-5p	ADSCs	Inhibitor	Exosome injection	Nrf2/GPX4	In vivo	Reduced pulmonary microvascular endothelial cells ferroptosis	Shen et al. (2023)
Spinal Cord Injury	lncGm36569	MSCs	Inhibitor	Exosome injection	miR-5627-5p/FSP1	In vivo	Improved behavioral scores, reduced inflammation	Shao et al. (2022)