REAGENT or RESOURCE	SOURCE	IDENTIFIER
Antibodies
Anti-M2-FLAG	Sigma Aldrich	F3165; RRID:AB_259529
Anti-β-tubulin	Sigma Aldrich	T5168; RRID:AB_477579
Anti-PCID2	Genetex	GTX52023
Anti-Histone H3	Abcam	ab1791; RRID:AB_302613
Anti-Flag® M2 Affinity gel	Sigma Aldrich	A-2220; RRID:AB_10063035
Anti-Histone H3Ac	Millipore	17-615; RRID:AB_1163437
Anti-Histone H3K36me3	Abcam	ab9050; RRID:AB_306966
Anti-Histone H3K27me3	Active Motif	39055; RRID: AB_2561020
Anti-p24 KC57-RD1	Beckman Coulter	6604667; RRID:AB_1575989
Bacterial and virus strains
DH5α	Thermo Fisher	18265017
Chemicals, peptides, and recombinant proteins
Phorbol 12-myristate 13-acetate	Sigma Aldrich	P8139
Valproic acid sodium salt	Sigma Aldrich	P4543
Prostratin	Sigma Aldrich	P007
K98	N/A	N/A
Actinomycin D	Sigma Aldrich	A4262
Anhydrous DMSO	Sigma Aldrich	276855-100mL
Molecular grade methanol-free 16% formaldehyde	Polysciences Inc.	18814
EDTA-free protease inhibitor cocktail	Roche	5056489001
DAPI-containing Fluorescent Mounting Media	Dako Omnis	S3023
TRI Reagent	Sigma Aldrich	93289
Critical commercial assays
Invitrogen™ PureLink™ HiPure Plasmid Miniprep Kit	Thermo Fisher	K210016
Dual-Glo® Luciferase Assay System	Promega	E2920
Protein A sepharose beads	GE Healthcare	17-0618-02
Protein G sepharose beads	GE Healthcare	17-0963-03
PrimeFlow RNA assay	Thermo Fisher	88-18005-204
EasySep Human CD4+ T cell enrichment kit	Stemcell Technologies	100-0696
Human T cell Nucleofector™ kit	Lonza	VPA-1002
Cell Line Nucleofector ™ kit R	Lonza	VCA-1001
High-capacity cDNA Reverse Transcription Kit	Applied Biosystems	4368814
GoTaq qPCR Master mix kit	Promega	A6001
DNAse I amplification grade Kit	Invitrogen	18068015
SuperScrip™t II reverse transcriptase	Invitrogen	18064014
Platinum™ Taq DNA Polymerase	Invitrogen	15966005
3’ mRNA-seq Library Prep Kit Protocol for Ion Torrent	QuantSeq-LEXOGEN	012
DNA High Sensitivity Kit	Agilent Technologies	5067-4626
Ion PI Hi-Q OT2 200 Kit	Thermo Fisher	A26434
Deposited data
MS raw data	This study	PRIDE: PXD043334
RNA sequencing data	This study	GEO: GSE249455
Experimental models: Cell lines
Jurkat cells	ATCC	TIB-152
J-Lat 11.1	(Jordan et al.53) Gifted by Eric Verdin	N/A
J-Lat 10.6	(Jordan et al.53) NIH Reagent Program	9854
J-Lat A2	(Jordan et al.53) NIH Reagent Program	9854
HEK 293T	ATCC	CRL-3216
Oligonucleotides
PCR primers	Integrated DNA Technologies	Tables 1 and 2
Recombinant DNA
sh Control	Sigma Aldrich	SHC002
sh PCID2	Sigma Aldrich	TRCN0000167267
sh PCID2	Sigma Aldrich	TRCN0000168656
sh IKZF1	Sigma Aldrich	TRCN0000107874
sh DSS1	Sigma Aldrich	TRCN0000083695
sh MCM3AP	Sigma Aldrich	TRCN0000147338
sh ENY2	Sigma Aldrich	TRCN0000285223
sh CETN3	Sigma Aldrich	TRCN0000055841
Lentiviral packaging construct pCMVΔR8.91	Naldini et al.54	N/A
VSV-G glycoprotein-expressing vector	Naldini et al.54	N/A
pBudCE4.1 (pBud control)	Sigma Aldrich	V53220
pBud-PCID2-Flag	This study	N/A
pNL4.3.Luc.R-.E-	NIH Reagent program	ARP-3418
pGL3-HSP	N/A	N/A
pRL Renilla	Promega	E2231
GagPol FISH-Flow probe	Thermo Fisher	VF10-10884
RPP30 FISH-Flow probe	Thermo Fisher
Software and algorithms
MaxQuant v2.1.3.0	Max Plank Institute of Biochemistry	https://www.maxquant.org/
Prism v8.3.0	GraphPad	https://www.graphpad.com/scientific-software/prism/
FlowJo v10	BD Biosciences	https://www.flowjo.com/
STRING database	STRING Consortium	https://string-db.org/