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. 2024 Jan 27;14(4):1371–1389. doi: 10.7150/thno.89878

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Upregulating p21/p27 in vitro duplicated similar phenotype with abPFs. (A) Schematic diagram showing the strategy of ovary culture in vitro. The DMSO group is set as a control. (B) Hematoxylin staining showing the follicular morphology of cultured ovaries. Dotted lines mark follicles. (C) p21 staining (green, top) and p-p27 staining (green, bottom) in cultured ovaries. (D) PCNA, BMI1 and MEL18 protein levels. (E) Number of follicles in cultured ovaries. n = 5. (F) GC thickness of follicles. n = 204 follicles (DMSO), n=200 follicles (AIL). (G) BrdU staining (green) in cultured ovaries. (H) Working model of PRC1 in GCs.