5. Sensitivity analysis—blinding.

Study ID	Arm removed	Analyses affected
Bateman 2013 [SHINE]	Tiotropium 18 mcg	SGRQ6m, FEV6m
Donohue 2010 [INHANCE]	Tiotropium 18 mcg	SGRQ6m, FEV6m
GLOW2 2012	Tiotropium 18 mcg	SGRQ6m, FEV6m, SGRQ12m, FEV12m
SPARK 2013	Whole study (2 arms)	SGRQ6m, FEV6m, SGRQ12m, FEV12m
Vogelmeier 2008	Tiotropium 18 mcg	Did not appear in analyses

FEV = forced expiratory volume in one second

SGRQ = St George's Respiratory Questionnaire

6m = six month analysis

12m = 12 month analysis