Table 1. Patient Characteristics.
| Characteristic | Patients, No. (%) | P value | ||
|---|---|---|---|---|
| All (N =1216) | Without recurrent event during follow-up (n = 1079) | With recurrent event during follow-up (n = 137) | ||
| Age, y | ||||
| Median (IQR) | 44.2 (38.4-47.7) | 44.1 (37.8-47.3) | 45.5 (40.6-48.3) | .006 |
| 18-29 | 124 (100) | 116 (93.5) | 8 (6.5) | .09 |
| 30-34 | 92 (100) | 86 (93.5) | 6 (6.5) | |
| 35-39 | 154 (100) | 139 (90.3) | 15 (9.7) | |
| 40-44 | 296 (100) | 262 (88.5) | 34 (11.5) | |
| 45-49 | 550 (100) | 476 (86.5) | 74 (13.5) | |
| Sex | ||||
| Male | 632 (52.0) | 554 (51.3) | 78 (56.9) | .25 |
| Female | 584 (48.0) | 525 (48.7) | 59 (43.1) | |
| Follow-up, median (IQR), y | 4.3 (2.6-6.0) | 4.3 (2.4-5.9) | 5.2 (3.1-6.8) | .001 |
| Stroke characteristics | ||||
| TOAST stroke classification | ||||
| Atherothrombotic | 52 (4.3) | 41 (3.8) | 11 (8.0) | .008 |
| Likely atherothrombotic | 166 (13.7) | 147 (13.6) | 19 (13.9) | |
| Small vessel disease | 165 (13.6) | 142 (13.2) | 23 (16.8) | |
| Cardioembolic | 200 (16.4) | 180 (16.7) | 20 (14.6) | |
| Rare cause | 130 (10.7) | 112 (10.4) | 18 (13.1) | |
| Cervical artery dissection | 144 (11.8) | 123 (11.4) | 21 (15.3) | |
| Cryptogenic | 302 (24.8) | 285 (26.4) | 17 (12.4) | |
| Multiple causes | 57 (4.7) | 49 (4.5) | 8 (5.8) | |
| National Institute of Health Stroke Scale score at admission, median (IQR)a | 3 (1-6) | 3 (1-6) | 3 (1-5) | |
| ≤3 (minor stroke) | 726 (59.7) | 644 (59.7) | 82 (59.9) | .54 |
| >3 (major stroke) | 486 (40.0) | 431 (39.9) | 55 (40.1) | |
| Vascular health factors | ||||
| Hypertension | 459 (37.7) | 387 (35.9) | 72 (52.6) | <.001 |
| Dyslipidemia | 801 (65.9) | 708 (65.6) | 93 (67.9) | .67 |
| Diabetes | 118 (9.7) | 92 (8.5) | 25 (18.2) | <.001 |
| Smoking | ||||
| Current | 267 (22.0) | 228 (21.1) | 39 (28.5) | .13 |
| Previousb | 459 (37.7) | 405 (37.9) | 54 (39.4) | |
| Excess alcohol use | 81 (6.7) | 67 (6.2) | 14 (10.2) | .11 |
| Illicit drug usec | 101 (10.2) | 89 (8.2) | 12 (8.8) | .59 |
| Obesity | 253 (20.8) | 222 (20.6) | 31 (22.6) | .66 |
| Use of oral contraceptivesd | 277 (47.4) | 251 (47.8) | 26 (44.1) | .27 |
| No. of vascular health factorse | ||||
| 0 | 136 (11.2) | 123 (11.4) | 13 (9.5) | <.001 |
| 1-2 | 661 (54.4) | 600 (55.6) | 61 (44.5) | |
| ≥3 | 419 (34.5) | 356 (33.0) | 63 (46.0) | |
Abbreviation: TOAST, Trial of ORG (danaparoid sodium [Orgaran]) 10172 in Acute Stroke Treatment.
a
The National Institute of Health Stroke Scale was not available for 4 patients.
b
A total of 115 patients reported ever having smoked, but it is not known whether they were smoking at time of event.
c
Information about illicit drug use was not available for 226 patients.
d
Percentage of oral contraceptives use was calculated for female participants only.
e
No. of vascular risk factors was determined by the presence of hypertension, dyslipidemia, diabetes, smoking, excess alcohol use, and obesity.