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. 2024 Jan 17;37(2):234–247. doi: 10.1021/acs.chemrestox.3c00255

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© 2024 The Authors. Published by American Chemical Society

Permits the broadest form of re-use including for commercial purposes, provided that author attribution and integrity are maintained (https://creativecommons.org/licenses/by/4.0/).

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Relative gene expression of XMEs in human tissue organoids after AAI treatment. RT-qPCR and the 2^–ΔΔCT method were used to determine CYP1A1, CYP1A2, and NQO1 expression in gastric (D95 and D88; A, C, and E) and kidney (D50 and D21; B, D, and F) organoids treated with the indicated AAI concentrations for 48 h. Values were normalized to mRNA expression of the housekeeping gene GAPDH and are relative to the vehicle control (0.1–1% water). Results are shown as mean ± SD (n ≥ 3). Statistical analysis was performed by log2 transforming the data and a one-sample t-test with Bonferroni correction against the control mean of 0 (*p < 0.05; **p < 0.01).