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Schematic representation of role of calcium in peroxisome. Calcium deficiency increases ROS accumulation by inhibiting catalase activity in peroxisomes and reduces phosphorylation of TFEB by inhibiting mTORC1 activity. Combining ROS accumulation, TFEB translocates to nucleus for autophagic degradation of peroxisome. Hence, pexophagy is induced by a calcium deficit via the ROS-mTORC1-TFEB pathway
