Table 2.
The behavior and complications of different POI rat models
| Group | Social behavior | Appearance | RGS | Hair | Ovaries weight | Complications | Death rate (%) | |||
|---|---|---|---|---|---|---|---|---|---|---|
| Orbital tightening | Nose/cheek flattening | Ear changes | Whisker change | |||||||
| Control | Active | Normal | 0 | 0 | 0 | 0 | Smooth, lightness | 0.083 ± 0.005 g | / | 0 |
| POI-C model | Dispirition | Distress | 2 | 1 | 1 | 0 | Rough, dinginess, | 0.068 ± 0.026 g | Bone marrow suppression; Hepatic nodules; bleeding (Nasal, orbital, Intestine) | 37.5 |
| POI-B model | Dispirition | Distress | 1 | 1 | 1 | 0 | Rough, dinginess | 0.07 ± 0.28 g | Urinary retention, bleeding (Nasal, orbital, Intestine) | 40 |
| POI-U model | Active | Normal | 0 | 0 | 0 | 0 | Smooth, lightness | 0.074 ± 0.016 | Injured blood vessels | 9 |
| MS model | Active | Normal | 0 | 0 | 0 | 0 | Smooth, lightness | 0.089 ± 0.008 g | Mental disorder (Schizophrenia or depression) | 0 |
NC3Rs: National Centre for the replacement Refinement & Reduction of Animal in Research; POI-C (cyclophosphamide); POI-B (Busulfan); POI-U (Ultrasound-guided cyclophosphamide injection); RGS: Rat Grimace Scale