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Non-invasive imaging of chemotherapy-induced senescence in vivo using probes NIR-BG1 or NIR-BG2. Both probes are at their fluorescence OFF state without the target enzyme SA-β-Gal. Upon activation by SA-β-Gal, both probes become fluorescent. NIR-BG2 is converted to an intermediate with electrophilic quinone methide, which reacts with endogenous cellular proteins in situ, increasing the detection sensitivity.
