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. 2005 May 2;102(19):6990–6995. doi: 10.1073/pnas.0500466102

Fig. 2.

Fig. 2.

Heat-stable tau fraction from the brainstem after lithium treatment. (A) Analysis of the heat-stable, soluble tau fraction from the brainstem showed no significant change in the amount of total tau (TG5, human and mouse tau) or human tau (CP27). After normalization to total levels of tau, lithium treatment resulted in decreased (P < 0.05) phosphorylation at GSK-3-directed sites, including Ser-202 (CP13) and Ser-396/404 (PHF-1). Sites not phosphorylated by GSK-3 (Ser-422 and Ser-262) appeared not to be affected in lithium-treated mice. Two representative data are displayed from five vehicle (Veh) and four LiCl-treated mice. *, P < 0.05. (B) These data were confirmed in another set of mice (vehicle, n = 5; LiCl, n = 6) showing reduction in tau phosphorylation at CP13 and PHF-1 epitopes (P < 0.05) but no change in total human tau levels (CP27). Two representative data are displayed.