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. 2005 May 2;102(19):6990–6995. doi: 10.1073/pnas.0500466102

Fig. 5.

Fig. 5.

Axonal degeneration and insoluble tau levels. (A) Section from the spinal cord of a vehicle-treated (Veh) mouse with high levels of insoluble tau stained with LFB. The asterisk represents a vacuole, the arrowhead represents a phagocyte, and the arrows indicate degenerating myelin. This mouse scored a 3 on overall degeneration. (B) Section from a lithium-treated mouse with low levels of insoluble tau stained with LFB. The arrows indicate glial nuclei. This mouse scored a 0 on overall degeneration (Scale bar, 60 μm.) (C) Correlation between insoluble tau levels and degree of axonal degeneration for PBS-treated mice (n = 12). There was a significant correlation between the level of insoluble tau and degeneration (R = 0.6, P = 0.01). (D) In 8-month-old mice treated with LiCl, there was a significant reduction in the level of axonal degeneration compared with vehicle-treated mice (n = 6 for each group). *, P < 0.05.