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. 2023 Sep 11;3:11622. doi: 10.3389/adar.2023.11622

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Copyright © 2023 Luque-Sanchez, Felix, Bilbrey, Restrepo, Reeves, McMahon and Wilkerson.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Mecamylamine (0.56 mg/kg) antagonism of discriminative stimulus (top row) and rate-decreasing (bottom row) effects in rats trained to discriminate 0.32 mg/kg nicotine from saline. (A) Mecamylamine abolishes the varenicline dose response function for the nicotine (0.32 mg/kg) discriminative stimulus, and (B) response rate effects. Mecamylamine abolishes the (C) RTI-36, (E) RTI-76, and (G) RTI-102 dose response curve in the substitution effects of the nicotine discriminative stimulus and (D, F, H) respective rate-decreasing effects. Top panels show drug-appropriate responding on the ordinates and drug dose in mg/kg (log scale) on the abscissae. The dashed line represents the percent responding on the nicotine-paired lever required to meet full discriminative stimulus criteria. Bottom panels show response rate normalized to saline control on the ordinates as function of drug dose in mg/kg (log scale) on the abscissae. Data reflect mean ± SEM, n = 7–8 rats (one rat was lost to attrition).