. 2023 Sep 11;3:11622. doi: 10.3389/adar.2023.11622

TABLE 1.

Drug Discrimination statistics.

	Alone		3.2 mg/kg DHβE pretreatment			0.56 mg/kg mecamylamine pretreatment
	Statistical Analysis	ED₅₀ (95% Confidence limits) mg/kg	Statistical Analysis	ED₅₀ (95% Confidence limits) mg/kg	Potency Ratio (DHβE/Alone)	Statistical Analysis	ED₅₀ (95% Confidence limits) mg/kg
Nicotine	F (7, 28) = 17.96 p < 0.0001	0.12 (0.09–0.17)	F (7, 14) = 24.30 p < 0.01	0.55 (0.47–0.63)	4.58 (3.70–5.22)	F (6, 25) = 1.115 p = 0.3622	N.A.
Varenicline	F (7, 38) = 11.49 p < 0.001	0.30 (0.21–0.42)	F (7, 42) = 16.60 p < 0.001	0.49 (0.38–0.63)	1.63 (0.90–3)	N.A.	N.A.
RTI-102	F (7, 35) = 10.57 p < 0.001	0.12 (0.09–0.17)	F (6, 24) = 5.970 p < 0.05	0.25 (0.19–0.34)	2.08 (2.00–2.11)	p = 0.4595	N.A.
RTI-76	F (7, 36) = 3.792 p < 0.05	0.20 (0.15–0.29)	F (6, 12) = 9.133 p < 0.05	0.41 (0.26–0.64)	2.05 (1.73–2.21)	F (6, 12) = 2.543 p = 0.1598	N.A.
RTI-36	F (7, 21) = 24.85 p < 0.0001	0.001 (0.0008–0.0012)	F (6, 18) = 5.387 p < 0.05	0.009 (0.003–0.031)	9.00 (3.75–25.83)	F (6, 18) = 0.7133 p = 0.4405	N.A.
Morphine	F (7, 14) = 0.6083 p = 0.5558	N.A.	N.A.	N.A.	N.A.	N.A.	N.A.