. 2024 Feb 21;132(2):027010. doi: 10.1289/EHP13684

Table 5.

Age-stratified ( $less than 50$ , 50–59, 60–69, and $greater than or equal to 70$ years of age) and adjusted RRs and 95% CIs from Poisson regressions for cancer incidence associated with cumulative atrazine intensity-weighted days of exposure compared to reported no atrazine use among agricultural health study cohort applicators from 1993 to 2017 ( $lowercase italic n equals 53,562$ total participants and 1,011,451 total person-years).

Cancer sites^a^,^b^,^c	$less than 50$						50–59					60–69					$greater than or equal to 70$
Cancer sites^a^,^b^,^c	Pesticide use^d	cases	RR	95% CI		$p$ -trend^e	cases	RR	95% CI		$p$ -trend^e	cases	RR	95% CI		$p$ -trend^e	cases	RR	95% CI		$p$ -trend^e	$p$ -interaction^f
All	Never	165	1.00	1.00	1.00	—	446	1.00	1.00	1.00	—	836	1.00	1.00	1.00	—	1061	1.00	1.00	1.00	—	—
	Ever	336	0.98	0.78	1.22	—	1,285	0.97	0.85	1.1	—	2,318	0.99	0.9	1.08	—	2,595	1.06	0.98	1.15	—	—
	Q1	87	0.86	0.65	1.15	—	321	0.93	0.80	1.09	—	545	0.98	0.86	1.1	—	638	1.03	0.93	1.15	—	—
	Q2	78	0.93	0.69	1.25	—	305	0.97	0.83	1.14	—	567	1.00	0.88	1.13	—	660	1.09	0.98	1.21	—	—
	Q3	78	0.92	0.67	1.25	—	319	0.99	0.84	1.16	—	574	0.98	0.86	1.11	—	634	1.06	0.96	1.19	—	—
	Q4	87	1.27	0.93	1.72	0.49	327	1.03	0.87	1.22	0.70	601	1.02	0.9	1.16	0.54	586	1.05	0.94	1.17	0.19	0.53
Non-Hodgkin lymphoid malignancies	Never	8	1.00	1.00	1.00	—	34	1.00	1.00	1.00	—	51	1.00	1.00	1.00	—	99	1.00	1.00	1.00	—	—
	Ever	45	2.43	1.10	5.38	—	116	0.74	0.48	1.13	—	167	1.00	0.70	1.43	—	229	0.94	0.71	1.24	—	—
	Q1	11	2.21	0.88	5.56	—	27	0.67	0.39	1.16	—	33	0.86	0.53	1.41	—	53	0.91	0.64	1.3	—	—
	Q2	14	2.84	1.12	7.21	—	28	0.76	0.44	1.3	—	40	1.05	0.66	1.68	—	57	0.92	0.64	1.31	—	—
	Q3	10	2.73	1.03	7.2	—	28	0.76	0.44	1.32	—	47	1.02	0.63	1.64	—	66	1.08	0.76	1.53	—	—
	Q4	9	2.53	0.88	7.27	0.03	31	0.84	0.49	1.46	0.42	45	1.11	0.69	1.78	0.53	46	0.82	0.55	1.21	0.69	0.60
Non-Hodgkin lymphoma, B-Cell	Never	8	1.00	1.00	1.00	—	30	1.00	1.00	1.00	—	48	1.00	1.00	1.00	—	95	1.00	1.00	1.00	—	—
	Ever	38	2.04	0.89	4.65	—	106	0.78	0.49	1.24	—	158	0.98	0.68	1.42	—	212	0.92	0.69	1.22	—	—
	Q1	10	2.04	0.79	5.3	—	25	0.71	0.40	1.27	—	32	0.88	0.53	1.45	—	49	0.89	0.61	1.28	—	—
	Q2	11	2.14	0.79	5.85	—	26	0.83	0.47	1.48	—	38	1.08	0.67	1.74	—	54	0.91	0.63	1.32	—	—
	Q3	8	2.21	0.79	6.18	—	24	0.75	0.42	1.35	—	44	0.99	0.61	1.62	—	59	1.03	0.71	1.48	—	—
	Q4	8	2.19	0.72	6.63	0.05	30	0.93	0.52	1.66	0.62	42	1.09	0.67	1.79	0.59	43	0.8	0.54	1.20	0.49	0.78
Mature B-cell lymphoma	Never	8	1.00	1.00	1.00	—	29	1.00	1.00	1.00	—	47	1.00	1.00	1.00	—	91	1.00	1.00	1.00	—	—
	Ever	35	1.79	0.78	4.09	—	100	0.77	0.48	1.23	—	155	0.99	0.68	1.43	—	203	0.91	0.68	1.21	—	—
	Q1	9	1.76	0.67	4.66	—	22	0.64	0.35	1.18	—	32	0.9	0.54	1.49	—	49	0.9	0.62	1.30	—	—
	Q2	9	1.61	0.56	4.63	—	25	0.85	0.47	1.52	—	38	1.1	0.68	1.79	—	51	0.9	0.62	1.32	—	—
	Q3	8	2.15	0.77	6.01	—	24	0.79	0.44	1.44	—	42	0.96	0.59	1.59	—	57	1.02	0.71	1.49	—	—
	Q4	8	2.20	0.73	6.65	0.04	28	0.92	0.51	1.67	0.84	41	1.09	0.66	1.8	0.62	39	0.75	0.49	1.13	0.35	0.84

Note: —, no data; AHS, Agricultural Health Study; CI, confidence interval; RR, rate ratio.

^{^a}

Main models were all adjusted for year of enrollment, biological sex, race, state of residence, pack-years of cigarette smoking, attained education, family history of cancer, and correlated pesticides (2, 4-D, alachlor, cyanazine, metolachlor, and glyphosate). Reproductive-related cancer sites were restricted to biological sex, and sex covariate was not included.

^{^b}

Some age-stratified sites with $less than 20$ exposed cases were collapsed into sequential age categories or completely removed due to data spareness.

^{^c}

Person-years for nonexposed (Never) and exposed applicators (Q1–Q4, T1–T3, or M1–M2), respectively, included the following age stratification: 39,862 and 51,495 ( $less than 50$ years old); 69,406 and 186,211 (50–59 years old); 77,074 and 247,043 (60–69 years old); and 89,179 and 240,607 ( $greater than or equal to 70$ years old).

^{^d}

Never cases are defined as participants that have not reported atrazine use at enrollment or at follow-up. Ever cases are defined as participants that have reported atrazine use at enrollment or at follow-up. Quantile cut points based on intensity-weighted days among any cancer cases for unlagged and lagged exposures. Quartiles Q0: 0 (no reported use); Q1: 2–918; Q2: 919–2,634; Q3: 2,635–7,370; Q4: $greater than or equal to 7,371$ . Tertiles T0: 0; T1: 2–1,343; T2: 1,344–5,207; T3: $greater than or equal to 5,208$ . Median M0: 0; M1: 2–2,634; M2: $greater than or equal to 2,635$ .

^{^e}

Linear trends based on the Wald test by using the median of each exposure category as a continuous variable.

^{^f}

Tests for interaction between categorical atrazine exposures and specified age categories using Type III Wald test.