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. 2023 Sep 20;9(38):eadg0488. doi: 10.1126/sciadv.adg0488

Fig. 6. scDNA + protein analysis enables simultaneous identification of donor cells and MRD.

Fig. 6.

(A) Aggregated deconvolution plot showing mutations detected and host-donor chimerism of post–allo-HSCT samples from six different patients included in the study. MRD6-S2 and MRD3-S3 were from the same patients; therefore, only the former is shown. MRD2-S2 had no mutations detected by either bulk NGS or scMRD assay. MRD4-S3 had an HDAC1 p.P243L mutation not covered by the scMRD panel. Refer to Fig. 4 for multiplex context for each of these samples. (B) Row-scaled heatmap of differential surface maker expression between donor and host cells in MRD1-S4. (C) Concordance of immunophenotype of MRD cells between MFC and scMRD in MRD1-S4. Number of cells analyzed for (B) and (C): donor WT = 97, Host WT = 6, and Host NPM1-mut = 13.