Skip to main content
. Author manuscript; available in PMC: 2024 Feb 21.
Published in final edited form as: Peptides. 2022 Jan 19;151:170748. doi: 10.1016/j.peptides.2022.170748

Figure 2: Expression of Ucn3 in PP cells.

Figure 2:

The expression of UCN3 is absent from pancreatic delta cells, but present in human and mouse PP cells, characterized by the expression of pancreatic polypeptide (Ppy/PPY). Human single cell RNA-seq data from [79] with the main endocrine cell clusters as defined by the expression of GCG, INS, SST and PPY (A). Expression of Crh is restricted to human alpha cells (B), while Ucn3 expression is detected in PP cells as well as in alpha and beta cells (C). Note how the mosaic detection of Crh and Ucn3 reflects dropout rather that biologically meaningful heterogeneous expression. The expression of UCN3 in PP cells is confirmed at the protein level by the observation that UCN3 and PPY overlap within the same cells of human pancreatic islets, as indicated by yellow areas. Blue arrow heads indicate overlap between UCN3 and insulin.