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. Author manuscript; available in PMC: 2024 Feb 21.
Published in final edited form as: Peptides. 2022 Jan 19;151:170748. doi: 10.1016/j.peptides.2022.170748

Figure 4: Overview of paracrine signaling in the islet involving UCN3.

Figure 4:

Beta cells co-secrete UCN3 along with insulin to activate its cognate receptor CRHR2α, which is selectively expressed on delta cells and amplifies SST negative feedback on alpha and beta cells. CRHR2 is a Gαs-coupled G-protein coupled receptor, which raises cAMP in delta cells to potentiate SST secretion. UCN3 is also expressed by alpha cells in primate, but not rodent islets.