Table 1.
Behavioral Phenotypes in Mef2c Mutant Mice
| Mef2c Mutant | Cre Driver | Locomotor Activity (Jump Count; Distance Traveled) | Y-Maze (% Correct Spontaneous Alternations) | Elevated Plus Maze (Time in Open Arms) | Social Preference | Fear Conditioning (Training, Context, Cue) |
|---|---|---|---|---|---|---|
| Mef2c+/− | Prm-cre | ↑♂;↑♂ | = | ↑ | ↓ | = |
| Mef2c cHetEmx1 | Emx1-cre | ↑♂;↑♂ | NA | ↑ | = | NA |
| Mef2c cHetCx3cr1 | Cx3cr1-cre | ↑♂;= | NA | = | ↓ | NA |
| Mef2c cHetVgat | Vgat-cre | =;= | ↓ | ↑♀ | ↓♀ | = |
| Mef2c cHetPcp2 | Pcp2-cre | = | NA | = | = | NA |
| Mef2c cHetPv | Pv-cre | = | NA | = | = | NA |
| Mef2c cHetSst | Sst-cre | = | = | = | = | = |
| Mef2c cHetVip | Vip-cre | ↑♂;= | = | = | = | = |
↑ indicates an increase compared with control mice; ↓ indicates a decrease compared with control mice; and = indicates no change compared with control mice.
cHet, conditional heterozygous; NA, not assessed.