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. 2024 Feb 16;35:429–444. doi: 10.1016/j.bioactmat.2024.02.016

Fig. 4.

Fig. 4

Transcriptomic analysis. (A) PCA of DEGs distributed in the blank group and RSD-MS group. (B) Comparative assessment of mRNA expression in the blank group and RSD-MS group. (C) Volcano plot representation of genes exhibiting significant expression changes exceeding a 2-fold difference in transcriptome sequencing results. (D) Heatmap of gene expression clustering for DEGs. (E) GO analysis for upregulated genes in BMSCs. (F) KEGG analysis for upregulated genes in BMSCs. (G–I) GSEA enrichment analysis for integrin-mediated cell adhesion pathway, focal adhesion pathway and glycosaminoglycan biosynthesis-chondroitin sulfate/dermatan sulfate in BMSCs.