Figure - PMC

Skip to main content

An official website of the United States government

Here's how you know

Here's how you know

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

View full-text article in PMC

. 2024 Feb 14;626(8000):827–835. doi: 10.1038/s41586-023-06968-8

Search in PMC
Search in PubMed
View in NLM Catalog
Add to search

© The Author(s) 2024

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

PMC Copyright notice

Extended Data Fig. 9 — a, Boxplots representing n = 1,000 independent individuals for IL-2 concentration levels depending on the genotype of the donors for the rs1801274 genetic variant before and after K-means clustering (2 groups) selection of responders. The centre line shows the median, hinges represent the 25th and 75th percentiles, and whiskers extend from the hinge to the largest or smallest value no further than the 1.5 interquartile range. Significance of two-sided Wilcoxon rank sum tests adjusting for multiple comparisons is indicated above the boxes (N.S, not significant; *P < 0.05, **P < 0.01, ***P < 0.001). P-values are from left to right on the top boxplot: <2.22e-16, <2.22e-16 and <2.22e-16 and on the bottom boxplot: <2.22e-16, 0.35 and 0.15. b, PCA performed on 261,827 independent SNPs and 1,723 individuals, which include the 1,000 MI donnors together with 723 individuals from a selection of 36 populations from North Africa, the Near East, as well as western and northern Europe. PC1 versus PC2 (top left), PC1 versus PC3 (bottom left) and PC2 versus PC3 (top right) are displayed as well as a barplot (bottom right) of the variance explained by the first 20 components of the PCA.