Table 1.

cis-pQTLs and trans-pQTLs for induced cytokines in each stimulation

Stimulus	Cytokine	rsID	Adjusted P value	cis or trans	Locus
E. coli	IFNγ	rs4833095	5.45 × 10−26	trans	TLR1/6/10 locus
	IL-2	rs9306967	2.83 × 10−33	trans	TLR1/6/10 locus
	IL-6	rs5743614	1.07 × 10−34	trans	TLR1/6/10 locus
	IL-8	rs4833095	5.64 × 10−52	trans	TLR1/6/10 locus
	IL-17a	rs9306967	9.24 × 10−21	trans	TLR1/6/10 locus
	IL-23a	rs6815814	4.50 × 10−30	trans	TLR1/6/10 locus
LPS	CXCL5	rs352045	5.13 × 10−15	cis	CXCL5 promoter
	IL-1β	rs3764613	1.96 × 10−10	trans	PPP5C enhancer
	IL-6	rs62449491	7.58 × 10−10	cis	IL6 enhancer
	IL-10	rs1518110	3.39 × 10−08	cis	IL10 intronic enhancer
	IL-12a/b	rs143060887	1.37 × 10−10	cis/trans	IL12A putative regulatory regions
SEB	IL-6	rs11936050	1.30 × 10−27	trans	TLR1/6/10 locus
Anti-CD3 + CD28 (responders)	CXCL5	rs352045	1.33 × 10−36	cis	CXCL5 promoter
	IL-2	rs1801274	2.09 × 10−22	trans	Close to FCGR2A
BCG	CXCL5	rs10013453	6.64 × 10−12	trans	TLR1/6/10 locus
	IL-2	rs4833095	1.01 × 10−66	trans	TLR1/6/10 locus
	IL-6	rs72636686	8.92 × 10−12	trans	KAZN intron
	IL-8	rs4833095	7.21 × 10−109	trans	TLR1/6/10 locus
C. albicans	CXCL5	rs10779330	9.21 × 10−16	trans	CR1 locus
	IL-1β	rs10863358	9.56 × 10−15	trans	CR1 locus
	IL-23a	rs10779330	2.70 × 10−10	trans	CR1 locus
	TNF	rs11117956	9.46 × 10−15	trans	CR1 locus
Influenza	CXCL5	rs352045	3.24 × 10−59	cis	CXCL5 promoter
	CXCL5	rs10822168	1.88 × 10−14	trans	JMJD1C intron
	IL-6	rs35345753	1.61 × 10−07	cis	IL6 enhancer
Poly I:C	CXCL5	rs352045	7.15 × 10−59	cis	CXCL5 promoter
	CXCL5	rs10822168	5.01 × 10−15	trans	JMJD1C intron
	IFNγ	rs3775291	1.36 × 10−13	trans	TLR3 exon
	IL-1β	rs3775291	1.76 × 10−24	trans	TLR3 exon
	IL-6	rs62449491	3.37 × 10−07	cis	IL6 enhancer
	IL-6	rs3775291	1.46 × 10−17	trans	TLR3 exon
	IL-12a/b	rs3775291	1.92 × 10−22	trans	TLR3 exon
	TNF	rs113845942	1.57 × 10−07	cis	HLA-DRB intergenic region
	TNF	rs3775291	4.78 × 10−19	trans	TLR3 exon
TNF	CSF2	rs112997843	1.11 × 10−09	trans	Intergenic region
	CXCL5	rs352045	1.95 × 10−22	cis	CXCL5 promoter
	IFNγ	rs352045	2.38 × 10−14	trans	CXCL5 promoter
	IL-10	rs6689179	1.58 × 10−07	cis	IL10 enhancer
IL-1β	CXCL5	rs352045	5.09 × 10−32	cis	CXCL5 promoter
	CXCL5	rs2393969	6.35 × 10−10	trans	JMJD1C intron
	IFNγ	rs2564594	1.07 × 10−11	trans	CXCL5 promoter
IFNγ	CXCL5	rs352045	8.06 × 10−58	cis	CXCL5 promoter
	CXCL5	rs10822168	1.49 × 10−14	trans	JMJD1C intron

Bonferroni adjusted P values of association (P < 0.05) obtained with MatrixEQTL using additive genotype effects (least squares model) are shown alongside the locus corresponding to each variant.