Table 1.

Whole brain volume analysis between two methods, DLS and Freesurfer with manual correction methods in the control group.

Parcellation region	Overall (n = 42, 100%)			Age ≤ 2 (n = 12, 28.6%)			2 < Age ≤ 6 (n = 18, 42.9%)			Age > 6 (n = 12, 28.6%)
	DLS, mean	Free-surfer, mean	p-value	DLS, mean	Free-surfer, mean	p-value	DLS, mean	Free-surfer, mean	p-value	DLS, mean	Free-surfer, mean	p-value
Total brain	1127.1	1073.4	0.014	1076.8	1036.3	0.123	1120.4	1044.8	0.030	1187.3	1153.3	0.848
Total GM	610.4	701.8	0.239	606.9	695.0	0.127	612.8	685.9	0.141	610.2	732.6	0.019
Cortical GM	566.3	547.6	0.006	565.0	545.4	0.012	569.1	540.2	0.135	563.5	560.8	1
Subcortical GM	44.1	55.9	< 0.001	41.9	53.3	< 0.001	43.7	54.0	< 0.001	46.7	61.5	< 0.001
Total WM	358.9	348.2	0.025	323.9	321.7	1	354.2	335.8	0.086	400.9	393.3	0.35
Total cerebellum	107.3	98.8	< 0.001	101.5	94.7	0.004	103.6	93.1	0.014	118.6	111.6	0.737
Cerebellar WM	21.2	23.9	< 0.001	17.7	20.2	0.019	20.6	23.6	0.014	25.7	28.1	0.28
Cerebellar GM	128.5	122.8	< 0.001	119.2	114.9	< 0.001	124.2	116.7	< 0.001	144.3	139.7	< 0.001
Total ventricle	13.3	14.1	0.01	12.7	13.0	1	13.6	14.2	0.039	13.7	14.9	0.135

Volume were normalized by ICV and expressed in mL.

The paired t test was applied.

Bold font indicates statistical significance (p < 0.001).

GM gray matter, WM white matter.