Table 3.
Subcortical volume analysis between the two methods, DLS and Freesurfer with manual correction methods in control group.
| Parcellation region | Overall (n = 42, 100%) | Age ≤ 2 years (n = 12, 28.6%) | 2 < Age ≤ 6 years (n = 18, 42.9%) | Age > 6 years (n = 12, 28.6%) | ||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| DLS, mean | Free-surfer, mean | p-value | DLS, mean | Free-surfer, mean | p-value | DLS, mean | Free-surfer, mean | p-value | DLS, mean | Free-surfer, mean | p-value | |
| Thalamus, left | 7.2 | 6.7 | < 0.001 | 6.9 | 6.3 | < 0.001 | 7.2 | 6.5 | 0.047 | 7.6 | 7.6 | 1 |
| Thalamus, right | 7.3 | 6.5 | < 0.001 | 7.0 | 6.2 | < 0.001 | 7.3 | 6.4 | < 0.001 | 7.7 | 7.1 | 0.002 |
| Putamen, left | 5.2 | 6.0 | < 0.001 | 5.0 | 5.7 | 0.034 | 5.0 | 5.7 | 0.075 | 5.6 | 6.7 | 0.005 |
| Putamen, right | 5.0 | 6.0 | < 0.001 | 4.8 | 5.8 | < 0.001 | 4.8 | 5.7 | 0.012 | 5.4 | 6.7 | < 0.001 |
| Caudate, left | 3.5 | 3.7 | < 0.001 | 3.4 | 3.5 | 1 | 3.6 | 3.7 | 0.477 | 3.7 | 3.9 | 0.117 |
| Caudate, right | 3.6 | 3.7 | 0.012 | 3.4 | 3.6 | 1 | 3.6 | 3.7 | 1 | 3.7 | 3.9 | 0.021 |
| Pallidum, left | 1.9 | 1.8 | 1 | 1.8 | 1.9 | 1 | 1.9 | 1.8 | 1 | 2.0 | 1.9 | 1 |
| Pallidum, right | 1.9 | 1.6 | 0.002 | 1.7 | 1.6 | 1 | 1.8 | 1.6 | 0.492 | 2.0 | 1.8 | 0.013 |
| Accumbens, left | 0.7 | 0.7 | 1 | 0.7 | 0.7 | 1 | 0.7 | 0.7 | 1 | 0.7 | 0.7 | 1 |
| Accumbens, right | 0.6 | 0.7 | 0.002 | 0.7 | 0.7 | 1 | 0.6 | 0.7 | 0.782 | 0.6 | 0.8 | 0.123 |
Volume were normalized by ICV and expressed in mL.
Paired t test and Bonferroni correction was applied.
Bold font indicates statistical significance (p < 0.001).