Table 5.
Dice coefficient | Precision | Recall | |||||||
---|---|---|---|---|---|---|---|---|---|
Total | Healthy control | SCN1A patients | Total | Healthy control | SCN1A patients | Total | Healthy control | SCN1A patients | |
Total brain | 0.79 | 0.79 | 0.80 | 0.80 | 0.79 | 0.80 | 0.80 | 0.80 | 0.81 |
Total GM | 0.80 | 0.80 | 0.80 | 0.81 | 0.80 | 0.81 | 0.80 | 0.80 | 0.81 |
Cortical GM | 0.78 | 0.77 | 0.78 | 0.78 | 0.78 | 0.78 | 0.79 | 0.78 | 0.79 |
Subcortical GM | 0.82 | 0.82 | 0.82 | 0.83 | 0.83 | 0.83 | 0.82 | 0.81 | 0.82 |
Total WM | 0.95 | 0.95 | 0.95 | 0.94 | 0.94 | 0.95 | 0.96 | 0.96 | 0.96 |
Total cerebellum | 0.90 | 0.90 | 0.90 | 0.90 | 0.90 | 0.90 | 0.90 | 0.90 | 0.90 |
Cerebellar WM | 0.87 | 0.87 | 0.87 | 0.89 | 0.89 | 0.88 | 0.86 | 0.85 | 0.87 |
Cerebellar GM | 0.92 | 0.92 | 0.92 | 0.90 | 0.90 | 0.91 | 0.94 | 0.94 | 0.93 |
Cortical volume analysis | |||||||||
Frontal | |||||||||
Superior frontal gyrus, left | 0.87 | 0.87 | 0.88 | 0.88 | 0.88 | 0.89 | 0.86 | 0.86 | 0.87 |
Superior frontal gyrus, right | 0.87 | 0.87 | 0.88 | 0.86 | 0.86 | 0.86 | 0.89 | 0.88 | 0.89 |
Rostral middle frontal, left | 0.85 | 0.85 | 0.85 | 0.86 | 0.86 | 0.85 | 0.84 | 0.84 | 0.85 |
Rostral middle frontal, right | 0.83 | 0.83 | 0.84 | 0.89 | 0.89 | 0.89 | 0.78 | 0.78 | 0.79 |
Caudal middle frontal, left | 0.80 | 0.79 | 0.81 | 0.78 | 0.77 | 0.80 | 0.82 | 0.82 | 0.82 |
Caudal middle frontal, right | 0.78 | 0.79 | 0.77 | 0.73 | 0.73 | 0.73 | 0.85 | 0.86 | 0.82 |
Pars opercularis, left | 0.81 | 0.81 | 0.82 | 0.82 | 0.81 | 0.83 | 0.81 | 0.81 | 0.81 |
Pars opercularis, right | 0.77 | 0.78 | 0.75 | 0.81 | 0.81 | 0.80 | 0.74 | 0.75 | 0.71 |
Pars triangularis, left | 0.82 | 0.82 | 0.81 | 0.83 | 0.83 | 0.83 | 0.81 | 0.81 | 0.80 |
Pars triangularis, right | 0.82 | 0.82 | 0.82 | 0.80 | 0.80 | 0.79 | 0.84 | 0.84 | 0.85 |
Pars orbitalis, left | 0.76 | 0.76 | 0.76 | 0.81 | 0.81 | 0.81 | 0.72 | 0.73 | 0.72 |
Pars orbitalis, right | 0.77 | 0.77 | 0.75 | 0.83 | 0.84 | 0.82 | 0.72 | 0.73 | 0.70 |
Lateral orbitofrontal, left | 0.85 | 0.84 | 0.86 | 0.82 | 0.82 | 0.82 | 0.89 | 0.88 | 0.90 |
Lateral orbitofrontal, right | 0.84 | 0.83 | 0.84 | 0.79 | 0.79 | 0.79 | 0.89 | 0.89 | 0.90 |
Medial orbitofrontal, left | 0.76 | 0.76 | 0.77 | 0.77 | 0.76 | 0.78 | 0.76 | 0.76 | 0.77 |
Medial orbitofrontal, right | 0.78 | 0.78 | 0.79 | 0.78 | 0.78 | 0.77 | 0.80 | 0.79 | 0.81 |
Precentral, left | 0.84 | 0.83 | 0.86 | 0.83 | 0.82 | 0.85 | 0.85 | 0.84 | 0.87 |
Precentral, right | 0.84 | 0.85 | 0.82 | 0.84 | 0.85 | 0.82 | 0.84 | 0.86 | 0.82 |
Paracentral, left | 0.78 | 0.77 | 0.79 | 0.78 | 0.76 | 0.81 | 0.79 | 0.78 | 0.80 |
Paracentral, right | 0.77 | 0.77 | 0.77 | 0.80 | 0.79 | 0.83 | 0.75 | 0.76 | 0.73 |
Frontal pole, left | 0.65 | 0.65 | 0.65 | 0.76 | 0.75 | 0.78 | 0.58 | 0.59 | 0.57 |
Frontal pole, right | 0.66 | 0.67 | 0.66 | 0.78 | 0.77 | 0.80 | 0.59 | 0.60 | 0.58 |
Rostral anterior cingulate, left | 0.78 | 0.78 | 0.79 | 0.76 | 0.76 | 0.75 | 0.82 | 0.81 | 0.83 |
Rostral anterior cingulate, right | 0.76 | 0.76 | 0.75 | 0.75 | 0.76 | 0.73 | 0.77 | 0.77 | 0.78 |
Caudal anterior cingulate, left | 0.72 | 0.72 | 0.73 | 0.75 | 0.75 | 0.73 | 0.71 | 0.70 | 0.74 |
Caudal anterior cingulate, right | 0.74 | 0.73 | 0.76 | 0.80 | 0.78 | 0.82 | 0.71 | 0.70 | 0.72 |
Parietal | |||||||||
Superior parietal, left | 0.83 | 0.82 | 0.85 | 0.82 | 0.80 | 0.85 | 0.84 | 0.84 | 0.86 |
Superior parietal, right | 0.81 | 0.80 | 0.83 | 0.79 | 0.78 | 0.82 | 0.84 | 0.84 | 0.84 |
Inferior parietal, left | 0.82 | 0.81 | 0.84 | 0.83 | 0.82 | 0.84 | 0.82 | 0.80 | 0.84 |
Inferior parietal, right | 0.83 | 0.82 | 0.84 | 0.85 | 0.85 | 0.86 | 0.81 | 0.80 | 0.82 |
Supramarginal, left | 0.81 | 0.81 | 0.83 | 0.83 | 0.82 | 0.85 | 0.80 | 0.79 | 0.81 |
Supramarginal, right | 0.82 | 0.83 | 0.81 | 0.85 | 0.86 | 0.85 | 0.80 | 0.81 | 0.79 |
Postcentral, left | 0.81 | 0.80 | 0.83 | 0.82 | 0.81 | 0.84 | 0.80 | 0.79 | 0.82 |
Postcentral, right | 0.79 | 0.79 | 0.77 | 0.79 | 0.80 | 0.78 | 0.78 | 0.79 | 0.77 |
Precuneus, left | 0.84 | 0.84 | 0.85 | 0.81 | 0.80 | 0.83 | 0.89 | 0.88 | 0.89 |
Precuneus, right | 0.83 | 0.83 | 0.84 | 0.80 | 0.79 | 0.81 | 0.87 | 0.87 | 0.88 |
Posterior cingulate, left | 0.79 | 0.78 | 0.80 | 0.77 | 0.76 | 0.79 | 0.80 | 0.80 | 0.82 |
Posterior cingulate, right | 0.78 | 0.77 | 0.78 | 0.74 | 0.75 | 0.74 | 0.82 | 0.81 | 0.83 |
Isthmus cingulate, left | 0.79 | 0.78 | 0.79 | 0.83 | 0.83 | 0.83 | 0.75 | 0.75 | 0.76 |
Isthmus cingulate, right | 0.76 | 0.75 | 0.76 | 0.82 | 0.82 | 0.82 | 0.70 | 0.70 | 0.72 |
Temporal | |||||||||
Superior temporal, left | 0.82 | 0.82 | 0.82 | 0.80 | 0.80 | 0.80 | 0.85 | 0.84 | 0.85 |
Superior temporal, right | 0.85 | 0.85 | 0.86 | 0.81 | 0.82 | 0.81 | 0.90 | 0.89 | 0.91 |
Middle temporal, left | 0.77 | 0.77 | 0.78 | 0.71 | 0.72 | 0.70 | 0.85 | 0.84 | 0.87 |
Middle temporal, right | 0.81 | 0.81 | 0.82 | 0.77 | 0.78 | 0.77 | 0.86 | 0.84 | 0.88 |
Inferior temporal, left | 0.72 | 0.72 | 0.71 | 0.70 | 0.71 | 0.68 | 0.74 | 0.74 | 0.75 |
Inferior temporal, right | 0.74 | 0.73 | 0.76 | 0.72 | 0.71 | 0.74 | 0.77 | 0.76 | 0.79 |
Banks of the sts, left | 0.68 | 0.68 | 0.67 | 0.68 | 0.70 | 0.66 | 0.68 | 0.67 | 0.70 |
Banks of the sts, right | 0.71 | 0.69 | 0.73 | 0.71 | 0.69 | 0.75 | 0.71 | 0.71 | 0.72 |
Fusiform, left | 0.73 | 0.74 | 0.73 | 0.76 | 0.75 | 0.77 | 0.72 | 0.72 | 0.71 |
Fusiform, right | 0.76 | 0.75 | 0.77 | 0.79 | 0.78 | 0.81 | 0.73 | 0.73 | 0.74 |
Transverse temporal, left | 0.77 | 0.77 | 0.77 | 0.73 | 0.73 | 0.73 | 0.81 | 0.81 | 0.82 |
Transverse temporal, right | 0.76 | 0.75 | 0.77 | 0.77 | 0.77 | 0.77 | 0.76 | 0.75 | 0.77 |
Entorhinal, left | 0.63 | 0.62 | 0.64 | 0.67 | 0.66 | 0.70 | 0.60 | 0.60 | 0.60 |
Entorhinal, right | 0.62 | 0.62 | 0.62 | 0.56 | 0.55 | 0.56 | 0.74 | 0.75 | 0.71 |
Temporal pole, left | 0.66 | 0.66 | 0.67 | 0.63 | 0.62 | 0.63 | 0.72 | 0.72 | 0.73 |
Temporal pole, right | 0.64 | 0.63 | 0.66 | 0.67 | 0.67 | 0.67 | 0.62 | 0.60 | 0.65 |
Parahippocampal, left | 0.77 | 0.76 | 0.78 | 0.83 | 0.83 | 0.84 | 0.72 | 0.71 | 0.73 |
Parahippocampal, right | 0.76 | 0.75 | 0.76 | 0.83 | 0.82 | 0.84 | 0.70 | 0.70 | 0.71 |
Occipital | |||||||||
Lateral occipital, left | 0.79 | 0.79 | 0.81 | 0.77 | 0.76 | 0.77 | 0.83 | 0.82 | 0.85 |
Lateral occipital, right | 0.78 | 0.78 | 0.78 | 0.69 | 0.69 | 0.69 | 0.89 | 0.89 | 0.90 |
Lingual, left | 0.79 | 0.79 | 0.80 | 0.75 | 0.74 | 0.75 | 0.85 | 0.85 | 0.86 |
Lingual, right | 0.80 | 0.80 | 0.81 | 0.79 | 0.79 | 0.79 | 0.81 | 0.81 | 0.83 |
Cuneus, left | 0.74 | 0.73 | 0.76 | 0.71 | 0.70 | 0.73 | 0.78 | 0.77 | 0.80 |
Cuneus, right | 0.75 | 0.75 | 0.75 | 0.77 | 0.76 | 0.77 | 0.73 | 0.73 | 0.73 |
Pericalcarine, left | 0.72 | 0.71 | 0.74 | 0.72 | 0.70 | 0.76 | 0.73 | 0.72 | 0.73 |
Pericalcarine, right | 0.74 | 0.73 | 0.75 | 0.67 | 0.65 | 0.69 | 0.84 | 0.83 | 0.84 |
Insular cortex, left | 0.84 | 0.84 | 0.84 | 0.81 | 0.81 | 0.80 | 0.88 | 0.87 | 0.89 |
Insular cortex, right | 0.85 | 0.85 | 0.85 | 0.85 | 0.85 | 0.85 | 0.85 | 0.85 | 0.86 |
Subcortical volume analysis | |||||||||
Hippocampus, left | 0.85 | 0.85 | 0.86 | 0.86 | 0.86 | 0.86 | 0.85 | 0.84 | 0.86 |
Hippocampus, right | 0.86 | 0.86 | 0.85 | 0.84 | 0.85 | 0.83 | 0.88 | 0.88 | 0.88 |
Thalamus, left | 0.88 | 0.88 | 0.88 | 0.88 | 0.88 | 0.88 | 0.88 | 0.88 | 0.89 |
Thalamus, right | 0.91 | 0.91 | 0.91 | 0.91 | 0.91 | 0.91 | 0.90 | 0.90 | 0.90 |
Putamen, left | 0.84 | 0.84 | 0.84 | 0.91 | 0.91 | 0.91 | 0.79 | 0.79 | 0.79 |
Putamen, right | 0.86 | 0.86 | 0.87 | 0.94 | 0.94 | 0.94 | 0.80 | 0.79 | 0.81 |
Caudate, left | 0.88 | 0.88 | 0.89 | 0.92 | 0.92 | 0.93 | 0.85 | 0.84 | 0.86 |
Caudate, right | 0.88 | 0.88 | 0.88 | 0.87 | 0.87 | 0.87 | 0.89 | 0.89 | 0.89 |
Pallidum, left | 0.76 | 0.77 | 0.75 | 0.75 | 0.76 | 0.72 | 0.78 | 0.78 | 0.78 |
Pallidum, right | 0.79 | 0.79 | 0.78 | 0.78 | 0.79 | 0.77 | 0.80 | 0.80 | 0.79 |
Accumbens, left | 0.71 | 0.70 | 0.73 | 0.69 | 0.68 | 0.70 | 0.75 | 0.74 | 0.77 |
Accumbens, right | 0.64 | 0.64 | 0.66 | 0.77 | 0.76 | 0.78 | 0.56 | 0.56 | 0.57 |
GM gray matter, WM white matter.