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. 2023 Aug 7;34(1):55–66. doi: 10.1007/s00062-023-01328-5

Table 2.

Group comparisons of demographic, serologic, electrophysiological, DCE perfusion parameters of the sciatic nerve and of compound z‑scores of quantitative sensory testing of controls and T2D participants with and without SFN

HC nDPN SFN p-value HC vs. nDPN HC vs. SFN nDPN vs. SFN
Ktrans (min−1) 0.031 ± 0.009 0.0474 ± 0.015 0.038 ± 0.153 0.034K 0.028 0.920 0.462
Ve (%) 1.2 ± 1.5 5.1 ± 5.4 2.8 ± 4.8 0.041K 0.034 0.754 0.649
Vp (%) 4.7 ± 0.5 4.5 ± 0.5 6.3 ± 5.1 0.450K 0.695 > 0.999 > 0.999
Age (years) 59.9 ± 7.2 64 ± 8.9 59.5 ± 11.50 0.405K 0.725 > 0.999 0.768
Gender 6w/4m 5w/5m 4w/4m 0.883K > 0.999 > 0.999 > 0.999
BMI (kg/m2) 25.7 ± 3.6 28.9 ± 4.5 27.6 ± 4.225 0.240A 0.215 0.590 0.800
Glucose (mg/dl) 92.9 ± 8.4 140.3 + 33.6 140.9 ± 49.15 0.001K 0.003 0.009 > 0.999
HbA1c (mmol/mol) 36.9 ± 6.9 49.7 ± 9.2 54.1 ± 18.7 0.003K 0.003 0.009 > 0.999
HbA1c (%) 5.5 ± 0.6 6.7 ± 0.9 7.1 ± 1.7 0.003K 0.010 0.008 > 0.999
eGFR (ml/min) 91.1 ± 13.2 85.1 ± 18.9 93.8 ± 14.3 0.012K > 0.999 0.708 0.228
Sural nerve NCV (m/s) 44.4 ± 3.4 47 ± 7.1 49.7 ± 9.7 0.424K 0.337 0.775 > 0.999
Sural nerve SNAP 10.6 ± 6.6 6.5 ± 4.2 6.4 ± 3.6 0.241K 0.396 0.543 > 0.999
Peroneal nerve NCV (m/s) 45.5 ± 4.2 42.6 ± 3.7 43.1 ± 7.0 0.405A 0.411 0.583 0.973
Tibial nerve NCV (m/s) 45.2 ± 4.4 43.0 ± 4.6 42.8 ± 6.9 0.548A 0.628 0.590 0.995
Compound z‑score of thermal detection −0.67 ± 0.54 −0.46 ± 0.83 −1.43 ± 1.35 0.092A 0.866 0.214 0.088
Compound z‑score of thermal pain 0.34 ± 0.66 −0.37 ± 0.80 −0.57 ± 0.90 0.810A 0.997 0.817 0.856
Compound z‑score of mechanical detection −0.53 ± 1.30 −0.63 ± 1.44 −1.29 ± 1.87 0.565A 0.989 0.572 0.652
Compound z‑score of mechanical pain 0.99 ± 0.95 1.301 ± 0.27 1.28 ± 0.83 0.584A 0.610 0.690 0.997

All values are displayed as mean ± standard deviation

Ktrans constant of permeability, vp plasma volume fraction, ve extracellular extravascular volume fraction, BMI body mass index, n.a. not applicable, eGFR glomerular filtration rate, NCV nerve conduction velocity, SNAP sensory nerve action potential

A p value obtained from ordinary one-way Anova and post hoc p values obtained from Tukeys multiple comparisons test

K p value obtained from Kruskal-Wallis-test and post hoc p values obtained from Dunn’s multiple comparisons test