Table 4.
Prognostic implications of atrial functional assessments according to subgroups
| Variable | NCD n = 34a HR (95% CI), p value |
masked HFpEF n = 18* HR (95% CI), p value |
overt HFpEF n = 15* HR (95% CI), p value |
|---|---|---|---|
| Echocardiography | |||
| STE LA Es rest | 0.80 (0.67–0.96), p = 0.018 | 0.89 (0.81–0.98), p = 0.016 | 0.88 (0.78–0.99), p = 0.032 |
| STE LA Es exercise | 0.96 (0.87–1.06), p = 0.422 | 0.91 (0.81–1.03), p = 0.137 | 0.91 (0.82–1.02), p = 0.120 |
| Conventional CMR at rest | |||
| FT LA Es | 0.86 (0.74–0.99), p = 0.038 | 0.95 (0.88–1.02), p = 0.157 | 0.93 (0.86–1.01), p = 0.074 |
| FT LA Ee | 0.85 (0.73–1.00), p = 0.054 | 0.93 (0.81–1.07), p = 0.326 | 0.87 (0.74–1.02), p = 0.095 |
| FT LA Ea | 0.93 (0.81–1.08), p = 0.335 | 0.94 (0.86–1.04), p = 0.230 | 0.90 (0.77–1.05), p = 0.165 |
| RT-CMR at rest and stress | |||
| LA EF Rest | 0.90 (0.80–1.01), p = 0.080 | 0.91 (0.83–1.00), p = 0.050 | 0.97 (0.91–1.03), p = 0.310 |
| LA EF Stress | 0.91 (0.82–1.01), p = 0.071 | 0.91 (0.84–0.99), p = 0.034 | 0.97 (0.91–1.04), p = 0.434 |
| LA LAS Rest | 0.89 (0.78–1.02), p = 0.101 | 0.88 (0.78–0.99), p = 0.037 | 0.80 (0.67–0.96), p = 0.017 |
| LA LAS Stress | 0.96 (0.84–1.09), p = 0.501 | 0.82 (0.71–0.95), p = 0.009 | 0.96 (0.86–1.07), p = 0.454 |
Hazard ratios (HR) were calculated by the means of cox regression analyses. Bold p-values indicate statistical significance
NCD non-cardiac dyspnoea, HFpEF heart failure with preserved ejection fraction, STE speckle-tracking echocardiography, LA left atrium, CMR cardiovascular magnetic resonance, FT feature-tracking, Es/Ee/Ea atrial reservoir/conduit/booster pump function, EF ejection fraction, LAS long axis strain
an numbers vary for echocardiographic assessments at rest/during exercise-stress: NCD: (n = 25/20), masked HFpEF: (n = 16/15), overt HFpEF: (n = 12/11)